Comparison of left atrium volume and right ventricle parameters in patients with chronic heart failurewith low ejection fraction
ORIGINAL PAPERS
Abstract
Introduction.The study of hemodynamic interaction and structural - functional dependence of the heart cavities is an important marker for assessing the severity of heart failure and the prognosis of the disease. In this study, a comprehensive clinical and instrumental examination was performed on patients with heart failure and significantly reduced ejection fraction.Aim—to evaluate the relationship between the volume of the left atrium and the parameters of the right ventricle in patients with chronic heart failure and reduced ejection fraction.Materials and methods.30 male patients with significantly reduced EF at the age of 54.5±11.8 years with dilatation of the heart cavities were examined. Based on the results of coronary angiography, as well as the clinical and laboratory parameters of the patients, the probable cause of dilatation cardiomyopathy was determined to be ischemic or idiopathic. Echocardiography was performed using the standard technique in two - dimensional mode by a single researcher with calculation of the contractility and area parameters of the right ventricle. Statistical data processing was carried out.Results.Despite the echocardiographic similarity of the structural changes in both groups, the analysis showed that in the ischemic group there was less correlation between dilatation processes occurring in the left chambers and similar changes in the right parts of the heart. There was also a higher diagnostic value of the right ventricular contractility index, the fractional area change (FAC, %), than the more traditional indicator, the tricuspid annular plane systolic excursion (TAPSE, mm).Conclusion.These findings help to better understand the etiopathogenetic relationships, which helps to improve the quality of diagnosis and, ultimately, prognosis in patients with this spectrum of pathology of the cardiovascular system.
References
1. Галявич А.С., Терещенко С.Н., Ускач Т.М., Агеев Ф.Т., Аронов Д.М., Арутюнов Г.П. и др. Хроническая сердечная недостаточность. Клинические рекомендации 2024. Российский кардиологический журнал. 2024. 29(11):6162. https://doi.org/10.15829/1560-4071-2024-6162. EDN: WKIDLJ.
2. Поляков Д.С., Фомин И.В., Беленков Ю.Н., Мареев В.Ю., Агеев Ф.Т., Артемьева Е.Г. и др. Хроническая сердечная недостаточность в Российской Федерации: что изменилось за 20 лет наблюдения? Результаты исследования ЭПОХА-ХСН. Кардиология. 2021. 61(4):4–14. https://doi.org/10.18087/cardio. 2021.4.n1628.
3. Шляхто Е.В., Звартау Н.Э., Виллевальде С.В., Яковлев А.Н., Соловьева А.Е., Федоренко А.А. и др. Значимость оценки распространенности и мониторинга исходов у пациентов с сердечной недостаточностью в России. Российский кардиологический журнал. 2020. 25(12):4204. https://doi.org/10.15829/1560-4071-2020-4204.
4. Армстронг У.Ф., Райан Т. Эхокардиография по Харви Фейгенбауму. М.: МЕДпресс-информ. 2023.
5. Флакскампф Ф.А. Практическая эхокардиография. М.: МЕДпресс - информ. 2019.
6. Chung-Yen L., Yosuke N., Tetsuji K., Parasca C.A., Calin A., Popescu B.A. et al. Prognostic value of right ventricular free - wall longitudinal strain in aortic stenosis: A systematic review and meta - analysis. Journal of Cardiology. 2024. 84(2):80–85. https://doi.org/10.1016/j.jjcc.2023.11.008.
7. Tantawi S., Issa E., Matli K., Farah R., Costanian C., Miner S. et al. Diagnostic and prognostic potential of left atrial strain in cardiovascular disease: a narrative review. Journal of Echocardiography. 2025. 23(2):69–85. https://doi.org/10.1007/s12574-024-00677-5.
8. Фомина И.Г., Георгадзе 3.О., Синицина М.Г., Гайдамакина Н.Е., Маркова 3.С., Возило Н.И. и др. Изменения сократимости правого желудочка у больных ишемической болезнью сердца и хронической сердечной недостаточностью. Российский кардиологический журнал. 2000. 1. Доступен по: https://medi.ru/info/357/ (дата_обращения:15.02.2026).
9. Naeije R., Badagliacca R. The overloaded right heart and ventricular interdependence. Cardiovascular Research. 2017. 113(12):1474–1485. https://doi.org/10.1093/cvr/cvx160.
10. Pieske B., Tschöpe C., de Boer R.A., Fraser A.G., Anker S.D., Donal E. How to diagnose heart failure with preserved ejection fraction: the H F A - P E F F diagnostic algorithm: a consensus recommendation from the Heart Failure Association (H F A) of the European Society of Cardiology (E S C). European Heart Journal. 2019. 40(40):3297–3317. https://doi.org/10.1093/eurheartj/ehz641.Erratum_in:European_Heart_Journal.2021.42(13):1274.https://doi.org/10.1093/eurheartj/ehaa1016.
11. Dai J., Ma L., Zhang Y., Shan L. et al. The prognostic value of HFA-PEFF score in connective tissue disease - associated PAH: evidence from a cohort study. BMC Cardiovascular disorders. 2025.25(1):258. https://doi.org/10.1186/s12872-025-04691-y.
12. Профстандарт: 02.025 Врач - кардиолог. Доступен по: https://classinform.ru/profstandarty/02.025-vrach-kardiolog.html (дата обращения:14.02.2026).
13. Suciu H., Anitei E.D., Calburean P., Harpa M.M. Right ventricular failure after LVAD support: A challenging case of bridge to heart transplantation in end - stage dilated cardiomyopathy. Journal of Critical Care Medicine (Targu Mures). 2026.12(1):102–109. https://doi.org/10.2478/jccm-2025-0038.
14. Kaveevorayan P., Tokavanich N., Kittipibul V., Lertsuttimetta Th., Singhatanadgige S., Ongcharit P. et al. Primary isolated right ventricular failure after heart transplantation: prevalence, right ventricular characteristics, and outcomes. Scientific Reports. 2023. 13:394. https://doi.org/10.1038/s41598-023-27482-x.
15. Gulati A., Ismail T.F., Jabbour A., Alpendurada F., Guha K, Ismail N.A. et al. The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy. Circulation. 2013. 128(15):1623–33. https://doi.org/10.1161/CIRCULATIONAHA.113.002518.
16. Gorter T.M., Hoendermis E.S., van Veldhuisen D.J., Voors A.A., Lam C.S. et al. Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta - analysis. European Journal of Heart Failure. 2016.18(12):1472–1487. https://doi.org/10.1002/ejhf.630.
17. Барбараш О.Л., Карпов Ю.А., Панов А.В., Акчурин Р.С., Алекян Б.Г., Алехин М.Н. и др. Стабильная ишемическая болезнь сердца. Клинические рекомендации 2024. Российский кардиологический журнал. 2024. 29(9):6110. https://doi.org/10.15829/1560-4071-2024-6110. EDN: HHJJUT.
18. Nuzzi V., Raafs A., Manca P., Henkens M.T.H.M., Gregorio C. et al. Left Atrial Reverse Remodeling in Dilated Cardiomyopathy. Journal of the American Society of Echocardiography. 2023. 36(2):154–162. https://doi.org/10.1016/j.echo.2022.10.017.
19. Korthals D., Eckardt L. The new European Society of Cardiology guideline for the management of cardiomyopathies: key messages for cardiac electrophysiologists. URL: https://link.springer.com/article/10.1007/s00399-023-00975-y (дата обращения: 14.02.2026).
20. Burke A.P. Dilated Cardiomyopathy Pathology. URL: https://emedicine.medscape.com/article/2017823-print (дата обращения: 15.02.2026).
21. Wong J., Marwick T.H. New insights in strain mechanics (LA, RA, and RV). Current cardiovascular imaging reports. 2023. 16:51–63. URL: https://doi.org/10.1007/s12410-023-09579-z (дата обращения: 16.02.2026).
22. Kosmala W. Heart failure with preserved ejection fraction and atrial fibrillation: how to fight allied enemies. Journal of the American College of Cardiology. 2020. 76(9):1065–1067. https://doi.org/10.1016/j.jacc.2020.07.024.
23. Schalla S., Jaarsma C., Bekkers S.C., Waltenberger J., Dennert R., Crijns H.J. et al. Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non - invasive imaging. Netherlands Heart Journal. 2015. 23(4):232–240. https://doi.org/10.1007/s12471-015-0673-x.
24. Berliner D., Hänselmann A., Bauersachs J. The treatment of heart failure with reduced ejection fraction. Deutsches Arzteblatt International. 2020. 117(21):376–386. https://doi.org/10.3238/arztebl.2020.0376.
25. Chamberlain A.M., Boyd C.M., Manemann S.M., Dunlay S.M., Gerber Y., Killian J.M. et al. Risk factors for heart failure in the community: differences by age and ejection fraction. The American Journal of Medicine. 2020.133(6):237–248. https://doi.org/10.1016/j.amjmed.2019.10.030.
26. Lavalle C., Mariani M.V., Severino P., Palombi M., Trivigno S., D’Amato A. et al. Efficacy of modern therapies for heart failure with reduced ejection fraction in specific population subgroups: a systematic review and network meta - analysis. Cardiorenal Medicine. 2024. 14(1):570–580. https://doi.org/10.1159/000541393.
27. Tian Y., Yang J., Lan M., Zou T. Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure. Aging (Albany N.Y). 2020. 12(24):26221–26235. https://doi.org/10.18632/aging.202405.
28. So-Armah K.A., Lim J.K., Lo Re V. 3rd, Tate J.P., Chang C.H., Butt A.A. et al. VACS Project Team. FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C. Progress in Cardiovascular Diseases. 2020. 63(2):184–191. https://doi.org/10.1016/j.pcad.2020.02.010.
29. Sun J., Xie Z., Ye M., Xu H., Dong Y., Liu C. et al. S2I2N0-3 score predicts short - and long - term mortality and morbidity in HFr EF: a post - hoc analysis of the GUIDE-IT trial. ESC Heart Failure. 2024. 11(3):1422–1434. https://doi.org/10.1002/ehf2.14689.
30. Surkova E., Kovács A. Современные эхокардиографические подходы к комплексной оценке функции правого желудочка. Российский кардиологический журнал. 2020. 25(3S):4067. https://doi.org/10.15829/1560-4071-2020-4067.



