Medicine: Theory and Practice

Study of the influence of isocimonic acid and specialized food products containing it on the dynamics of blood oxygen transport system and hemostasis in professional football players

ORIGINAL PAPERS

Keywords:
isocitric acid Krebs cycle energy metabolism substrates antioxidants antihypoxants hypocoagulation coagulogram football iron metabolism изолимонная кислота цикл Кребса субстраты энергетического обмена антиоксиданты антигипоксанты гипокоагуляция коагулограмма футбол обмен железа

Abstract

Introduction. In modern sports medicine, and in football in particular, there is an urgent need to find new safe substances capable of optimizing metabolic processes in athletes under hypoxic conditions during professional workloads. One of the promising substances classified as potential antihypoxants is isocitric acid. It removes the block of succinate dehydrogenase in the Krebs cycle, which reduces the speed of the entire cycle and, consequently, energy production, and also decreases oxygen consumption. Aim. To study the effect of isocitric acid and supplemental nutritional supplement containing it on the dynamics of individual laboratory parameters of the hemostasis, erythropoiesis, and iron metabolism systems. Material and methods. A blinded, randomized, placebo-controlled study of the effect of isocitric acid and supplemental nutritional supplement based on it on the dynamics of individual laboratory parameters of the oxygen transport system and hemostasis was conducted on professional football players during the competitive stage of the annual training cycle. Results. In football players taking 200 mg of isocitric acid, statistically significant changes were observed in oxygen transport system parameters: transferrin saturation percentage and serum iron content decreased, and unsaturated iron-binding capacity of serum increased. In football players taking 100 mg of isocitric acid as part of a supplemental nutritional supplement, hemoglobin levels increased and red blood cell count decreased. In football players taking 200 mg of isocitric acid or 100 mg of isocitric acid as part of a supplemental nutritional supplement, similar dynamics of coagulation parameters were observed: statistically significant increases were observed in activated partial thromboplastin time, international normalized ratios, and prothrombin time, while statistically significant decreases were observed in such parameters as the prothrombin index and fibrinogen, which indicates a targeted effect of isocitric acid on the hemostatic system — hypocoagulation. Conclusion. Isocitric acid improves adaptation to moderate hypoxia, which leads to metabolic restructuring, improved rheological properties of the blood and, as a consequence, to increased performance, especially in anaerobic conditions.

Author Biographies

Zhanna V. Grishina, National Center for Sports Medicine of the Federal Medical and Biological Agency

Cand. Sci. (Biol.), biochemist at the Sports Dietetics and Nutritional Support Department

Elena V. Lomazova, National Center for Sports Medicine of the Federal Medical and Biological Agency

Cand. Sci. (Med.), sports medicine physician of the department of medical support for sports teams and competitions

Timofei A. Yashin, National Center for Sports Medicine of the Federal Medical and Biological Agency; Football Club “Spartak-Moscow”

Head of the Sports Dietetics and Nutritional Support Department, National Center for Sports Medicine of the Federal Medical and Biological Agency; nutrition support specialist, Football Club “Spartak-Moscow”

Nikita S. Gladyshev, National Center for Sports Medicine of the Federal Medical and Biological Agency

Junior Researcher of the Research Department

Sergei A. Parastaev, National Center for Sports Medicine of the Federal Medical and Biological Agency; Pirogov Russian National Research Medical University

Dr. Sci. (Med.), Professor of the Department of Rehabilitation, Sports Medicine and Physical Education, Pirogov Russian National Research Medical University; Chief Researcher of the Research Services Department, National Center for Sports Medicine of the Federal Medical and Biological Agency

Aleksandr A. Derevoedov, National Center for Sports Medicine of the Federal Medical and Biological Agency

Cand. Sci. (Med.), Leading Researcher of the Research Department

Kirill V. Kozlov, National Center for Sports Medicine of the Federal Medical and Biological Agency; Football Club “Spartak-Moscow”

Head of the Medical Department; sports medicine physician, Football Club “Spartak-Moscow”

Pavel A. Dekhanov, Football Club “Spartak-Moscow”

sports medicine physician

Vladimir V. Zavyalov, National Center for Sports Medicine of the Federal Medical and Biological Agency

sports medicine physician, Department of Medical Support for Sports Teams and Competitions

Andrei V. Kalinin, Saint Petersburg State Pediatric Medical University; Lesgaft National State University of Physical Education, Sports, and Health; Almazov National Medical Research Center

Dr. Sci. (Med.), Professor of the Department of Medical Rehabilitation and Sports Medicine, Saint-Petersburg State Pediatric Medical University; Director of the Institute of Health and Rehabilitation, Lesgaft National State University of Physical Education, Sports, and Health; Professor of the Department of Faculty Therapy, Almazov National Medical Research Center

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How to Cite
Study of the influence of isocimonic acid and specialized food products containing it on the dynamics of blood oxygen transport system and hemostasis in professional football players: ORIGINAL PAPERS. (2026). Medicine: Theory and Practice, 11(2), 71-81. https://doi.org/10.56871/
Issue
Vol. 11 No. 2 (2026)
Section
ORIGINAL PAPERS
Published
2026-08-11

How to Cite

Study of the influence of isocimonic acid and specialized food products containing it on the dynamics of blood oxygen transport system and hemostasis in professional football players: ORIGINAL PAPERS. (2026). Medicine: Theory and Practice, 11(2), 71-81. https://doi.org/10.56871/

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