Клинические исходы вестибулопластики при внедрении комплексной программы медицинской реабилитации у пациентов с локальным дефицитом мягких тканей полости рта: исследование типа «случай–контроль»: ОРИГИНАЛЬНЫЕ СТАТЬИ

Михаил Арменакович Власов; Евгений Васильевич Яковлев; Дмитрий Юрьевич Бутко; Владимир Станиславович Василенко; Марина Васильевна Калинина; Лариса Андреевна Даниленко; Сергей Степанович Рогозин; Эльнур Эльданиз Оглы Гулиев

doi:10.56871/

Clinical outcomes of vestibuloplasty with implementation of a comprehensive medical rehabilitation programin patients with local soft tissue deficiencyof the oral cavity: a case-control study

ORIGINAL PAPERS

Mikhail A. Vlasov Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-9673-6703
Evgeny V. Yakovlev Saint Petersburg State Pediatric Medical University; Institute of Applied Psychoanalysis and Psychology of the University under the Interparliamentary Assembly of the Eur As EC https://orcid.org/0000-0002-8435-7562
Dmitry Yu. Butko Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-6284-0943
Vladimir S. Vasilenko Saint Petersburg State Pediatric Medical University
Marina V. Kalinina Saint Petersburg State Pediatric Medical University https://orcid.org/0009-0004-5809-1651
Larisa A. Danilenko Saint Petersburg State Pediatric Medical University https://orcid.org/0009-0009-4452-044X
Sergey S. Rogozin Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-9263-0111
Elnur E. Guliyev Saint Petersburg State Pediatric Medical University

Keywords:

vestibuloplasty digital 3D planning rehabilitation treatment physiotherapy вестибулопластика цифровое 3D-планирование восстановительное лечение физиотерапия стоматологическая реабилитация случай–контроль нормобарическая гиперокситерапия

Abstract

Introduction. Currently, there is an increase in oral pathologies in adults and children, which leads to an increase in the prevalence of surgical interventions in oral cavity. Therefore, the task of testing, developing and implementing comprehensive methods of dental rehabilitation is relevant. The aim of this paper is to study the relationship between complications after vestibuloplasty surgery and the applied program of planning and therapeutic and restorative treatment. Materials and methods. The study involved 281 patients, men and women aged 18 to 76 years, who underwent vestibuloplasty for tooth recession in the lower and upper jaws. Volunteers were divided into two groups: “control” (n=176, vestibuloplasty without digital planning, photobiotherapy and medicinal electrophoresis of Fermencol gel) and “cases” (n=105, vestibuloplasty with digital planning using Sulfacrylate glue, photobiotherapy, Fermencol gel, normobaric hyperoxytherapy). All volunteers were assessed for bleeding within the first three days, difficulty eating, inflammation at the donor and recipient sites, and postoperative bleeding. These parameters were compared using the Pearson chisquare test by calculating the odds ratio (OR) and their 95% confidence intervals (95% CI). Results. When using the proposed recovery program, bleeding is less common in the first three days after surgery (OR 0.11; 95% CI 0.05–0.22; p <0.0001), the likelihood of difficulty eating is lower (OR 0.32; 95% CI 0.19–0.54; p <0.0001), the frequency of inflammation in the donor (OR 0.19; 95% CI 0.09–0.38; p <0.0001) and recipient sites (OR 0.19; 95% CI 0.10–0.34; p <0.0001) is lower, and postoperative bleeding is less common (OR 0.05; 95% CI 0.02–0.11; p <0.0001). Conclusions. The studied algorithm can be recommended for complex restorative treatment in patients undergoing vestibuloplasty.

Author Biographies

Mikhail A. Vlasov, Saint Petersburg State Pediatric Medical University

Assistant of the Department of Medical Rehabilitation and Sports Medicine.

Evgeny V. Yakovlev, Saint Petersburg State Pediatric Medical University; Institute of Applied Psychoanalysis and Psychology of the University under the Interparliamentary Assembly of the Eur As EC

Dr. Sci. (Med.), Associate Professor, Professor of the Department of Medical Rehabilitation and Sports Medicine, Saint Petersburg State Pediatric Medical University; Professor of the Department of Psychophysiology, Institute of Applied Psychoanalysis and Psychology of the University of the Interparliamentary Assembly of Eur As EC.

Dmitry Yu. Butko, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor, Head of the Department of Medical Rehabilitation and Sports Medicine

Vladimir S. Vasilenko, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy
with a Course in Endocrinology

Marina V. Kalinina, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor of the Department of Medical Rehabilitation and Sports Medicine

Larisa A. Danilenko, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor of the Department of Medical Rehabilitation and Sports Medicine.

Sergey S. Rogozin, Saint Petersburg State Pediatric Medical University

specialist, Department of Scientific and Medical Information and Publications

Elnur E. Guliyev, Saint Petersburg State Pediatric Medical University

Laboratory Assistant, Department of Scientific and Medical Information and Publications.

References

1. Jin L.J., Lamster I.B., Greenspan J.S., Pitts N.B., Scully C., Warnakulasuriya S. Global burden of oral diseases: emerging concepts, management and interplay with systemic health. Oral Dis. 2016. 22(7):609–619. https://doi.org/10.1111/odi.12428.

2. Kassebaum N.J., Smith A.G.C., Bernabé E., Fleming T.D., Reynolds A.E., Vos T. et al. G B D 2015 Oral Health Collaborators. Global, Regional, and National Prevalence, Incidence, and Disability - Adjusted Life Years for Oral Conditions for 195 Countries, 1990–2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J Dent Res. 2017. 96(4):380–387. https://doi.org/10.1177/0022034517693566.

3. Chapple I.L., Bouchard P., Cagetti M.G., Campus G., Carra M.C., Cocco F. et al. Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint E F P/O R C A workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol. 2017. 44(Suppl. 18):S39–S51. https://doi.org/10.1111/jcpe.12685.

4. Osman M.A.K., Aljezoli M.H.I., Alsadig M.A.M., Suliman A.M. Referral pattern of oral and maxillofacial surgery cases in Sudan: A retrospective age - and sex - specific analysis of 3,478 patients over four years. Plos One. 2021. 16(3):e0249140. https://doi.org/10.1371/journal.pone.0249140.

5. Meisgeier A., Pienkohs S., Salomia C., Moosdorf L., Neff A. Epidemiologic trends and increasing inequalities in orthognathic surgery in Germany: a nationwide analysis 2005–2022. Sci Rep. 2025. 15(1):6223. https://doi.org/10.1038/s41598-025-90889-1.

6. Информационные бюллетени В О З. Здоровье полости рта. Url: https://www.who.int/ru/news_room/fact_sheets/detail/oral_health_(дата_обращения:05.12.2025).

7. Babaki D., Khoshsimaybargard M., Yaghoubi S., Gholami M. Comparison of Vestibular Depth Relapse and Wound Healing After Reconstructive Preprosthetic Surgery Using Cryopreserved Amniotic Membrane and Acellular Dermal Matrix — A Comparative Study. Ann Maxillofac Surg. 2021. 11(1):12–16. https://doi.org/10.4103/ams.ams_322_20.

8. Власов М.А., Яковлев Е.В., Бутко Д.Ю., Еркудов В.О., Божков И.А., Живолупов С.А. и др. Применение алгоритма диагностики и медицинской реабилитации у пациентов с локальным дефицитом мягких тканей в полости рта после реконструктивных оперативных вмешательств с применением цифрового 3D - моделирования. Медицинский совет. 2025. 19(23):228–238. https://doi.org/10.21518/ms2025-343.

9. Власов М.А., Колсанов А.В., Яковлев Е.В., Смирнов А.А., Бутко Д.Ю., Живолупов С.А., Гаврилова Т.А. Персонализированная литниковая система для моделирования и отработки техники забора и имплантации десневого лоскута. Патент Рф R U 233861 U1. 07 мая 2025.

10. Иванов Д.О., Яковлев Е.В., Бутко Д.Ю., Власов М.А., Даниленко Л.А., Калинина М.В., Баранцевич Н.Е. Программа для определения индекса в выборе оптимальной методики восстановительного лечения при реконструктивных операциях на мягких тканях зубочелюстной системы CMSI 1.0. Свидетельство о государственной регистрации программы для Э В М № 2025618147. 02 апреля 2025.

11. Oleksy M., Dynarowicz K., Aebisher D. Rapid Prototyping Technologies: 3D Printing Applied in Medicine. Pharmaceutics. 2023. 15(8):2169. https://doi.org/10.3390/pharmaceutics15082169.

12. Jeong M., Radomski K., Lopez D. et al. Materials and Applications of 3D Printing Technology in Dentistry: An Overview. Dent J (Basel). 2023. 12(1):1. https://doi.org/10.3390/dj12010001.

13. Sun T.C., Chang T.K., Soft tissue management around dental implant in esthetic zone the current concepts and novel techniques. J Dent Sci. 2024. 19(3):1348–1358. https://doi.org/10.1016/j.jds.2024.03.003.

14. Zuhr O., Akakpo D., Eickholz P., Vach K., Hürzeler M.B., Petsos H. Research Group for Oral Soft Tissue Biology & Wound Healing. Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivate for root coverage: 5 - year results of an R C T using 3D digital measurement technology for volumetric comparison of soft tissue changes. J Clin Periodontol. 2021. 48(7):949–961. https://doi.org/10.1111/jcpe.13470.

15. César Neto J.B., Cavalcanti M.C., Silva C.O., Almeida V.C., Sapata V.M., Lazarin R.O. et al. Digital three - dimensional assessment of free gingival graft remodeling over 12 months. J Dent. 2024. 148:105216. https://doi.org/10.1016/j.jdent.2024.105216.

16. Gogoi A., Enhancing Gingival Phenotype With Vestibuloplasty and Free Gingival Graft: Improving Maintenance of Regular Oral Hygiene. Cureus. 2022. 14(3):e23642. https://doi.org/10.7759/cureus.23642.

17. Апресян С.В., Степанов А.Г., Варданян Б.А. Цифровой протокол комплексного планирования стоматологического лечения. Анализ клинического случая. Стоматология. 2021. 100(3):65–71. https://doi.org/10.17116/stomat202110003165.

18. Мамедов С.К., Гусейнов Н.А., Ивашкевич С.Г., Ивашкевич С.Г., Мухаметшин Р.Ф., Лежава Н.Л. и др. Экспериментальное обоснование применения хирургических навигационных шаблонов. Клиническая стоматология. 2023. 26(2):144–149. https://doi.org/10.37988/1811-153X_2023_2_144.

19. Lacerda-Santos J.T., Granja G.L., Firmino R.T., Dias R.F., de Melo D.P., Granville-Garcia A.F., Martins C.C. Use of Photobiomodulation to Reduce Postoperative Pain, Edema, and Trismus After Third Molar Surgery: A Systematic Review and Meta - Analysis. J Oral Maxillofac Surg. 2023. 81(9):1135–1145. https://doi.org/10.1016/j.joms.2023.05.007.

20. Giansiracusa A., Parrini S., Baldini N., Bartali E., Chisci G. The Effect of Photobiomodulation on Third Molar Wound Recovery: A Systematic Review with Meta - Analysis. J Clin Med. 2024. 13(18):5402. https://doi.org/10.3390/jcm13185402.

21. Morshedzadeh G., Aslroosta H., Vafaei M. Effect of Ga Al As 940 nm Photobiomodulation on palatal wound healing after free gingival graft surgery: a split mouth randomized controlled clinical trial. B M C Oral Health. 2022. 22(1):202. https://doi.org/10.1186/s12903-022-02229-8.

22. Camolesi G.C.V., Somoza-Martín J.M., Reboiras-López M.D., Camacho-Alonso F., Blanco-Carrión A., Pérez-Sayáns M. Photobiomodulation in dental implant stability and post - surgical healing and inflammation. A randomised double - blind study. Clin Oral Implants Res. 2023. 34(2):137–147. https://doi.org/10.1111/clr.14026.

23. Thomas D.C., Tsu C.L., Nain R.A., Arsat N., Fun S.S., Sahid Nik Lah N.A. The role of debridement in wound bed preparation in chronic wound: A narrative review. Ann Med Surg (Lond). 2021. 71:102876. https://doi.org/10.1016/j.amsu.2021.102876.

24. Amadeh A., Mohebbi N., Amadeh Z., Jamshidbeigi A. Comparative Efficacy of Autolytic and Collagenase - Based Enzymatic Debridement in Chronic Wound Healing: A Comprehensive Systematic Review. Int Wound J. 2025. 22(4):e70177. https://doi.org/10.1111/iwj.70177.

25. Гриднева Т.Д., Диш А.Ю., Трухачев И.Г. Опыт реабилитации в раннем периоде производственной травмы. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2021. 98(3-2);65. E D N: I U F W M K.

26. Escobar M., Pauletto P., Benfatti C.A.M., Cruz A.C.C., Flores-Mir C., Henriques B.A.P.C. Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review. Clin Oral Investig. 2021. 25(6):3609–3622. https://doi.org/10.1007/s00784-020-03683-w.

27. Veríssimo A.H., Ribeiro A.K.C., Martins A.R.L.A., Gurgel B.C.V., Lins R.D.A.U. Comparative analysis of the hemostatic, analgesic and healing effects of cyanoacrylate on free gingival graft surgical wounds in donor and recipient areas: a systematic review. J Mater Sci Mater Med. 2021. 32(9):98. https://doi.org/10.1007/s10856-021-06573-z.

28. Ngeow W.C., Tan C.C., Goh Y.C., Deliberador T.M., Cheah C.W. A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing. Bioengineering (Basel). 2022. 9(11):636. https://doi.org/10.3390/bioengineering9110636.

29. Kasikasetsiri J., Apaijai N., Aschaitrakool Y., Kerdphoo S., Sriyaranya N., Chattipakorn N., Chattipakorn S.C. Hyperbaric oxygen therapy restores wound healing in irradiated gingiva to a similar level to that in healthy gingiva. J Wound Care. 2023. 32(10):676–684. https://doi.org/10.12968/jowc.2023.32.10.676.

30. Helmers R., Milstein D.M., van Hulst R.A., de Lange J. Hyperbaric oxygen therapy accelerates vascularization in keratinized oral mucosal surgical flaps. Head Neck. 2014. 36(9):1241–1247. https://doi.org/10.1002/hed.23437.

31. Liao J., Ren J., Qing W., Mu YD., Li P. Impact of Hyperbaric Oxygen on the Healing of Teeth Extraction Sockets and Alveolar Ridge Preservation. Clin Oral Investig. 2020. 24(8):2591–2601. https://doi.org/10.1007/s00784-019-03117-2.

32. Yang S., Li Y., Liu C., Wu Y., Wan Z., Shen D. Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction. Front Endocrinol (Lausanne). 2022. 13:949535. https://doi.org/10.3389/fendo.2022.949535.

Clinical outcomes of vestibuloplasty with implementation of a comprehensive medical rehabilitation programin patients with local soft tissue deficiencyof the oral cavity: a case-control study: ORIGINAL PAPERS. (2026). Medicine: Theory and Practice, 11(2), 7-16. https://doi.org/10.56871/

Download Citation

How to Cite