FEATURES OF THE FUNCTIONAL STATE OF THE ENDOTHELIUM AND HEMODYNAMICS OF THE LEFT VENTRICLE IN THE PROGRESSION OF CHRONIC PULMONARY HEART IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Abstract
Background. Chronic pulmonary heart, being a complication of chronic obstructive pulmonary disease, largely determines the clinic, the rate of progression and prognosis of the underlying disease. The study of the relationship between the right and left ventricle in patients with chronic pulmonary heart against the background of progressive bronchial obstruction is an urgent problem, since the addition and progression of biventricular heart failure leads to refractory therapy and a significant deterioration in the prognosis of patients. Aim is to study the features of the hemodynamics of the left ventricle and the functional state of the endothelium during the progression of the chronic pulmonary heart in patients with chronic obstructive pulmonary disease. Materials and methods. The study included 120 patients with chronic pulmonary heart disease on the background of chronic obstructive pulmonary disease. The average age of the examined was 55.2 ± 1.2 years. In accordance with the goals and objectives of the study, the features of the hemodynamics of the left ventricle and the functional state of the endothelium in the progression of chronic pulmonary heart in patients with chronic obstructive pulmonary disease were evaluated. Results. As part of the study, the relationship between the hemodynamic parameters of the right and left ventricles was revealed, indicating a close interventricular interaction, which is maximally manifested in patients with chronic pulmonary heart disease and stage IIB CHF. Endothelial dysfunction manifests itself both with compensated chronic pulmonary heart and with the progression of heart failure, while the severity of pathological changes is associated with the progression of changes in intracardiac and pulmonary hemodynamics. Conclusion. The data obtained will expand the possibilities of early diagnosis, prognosis, correction of treatment and rehabilitation at the outpatient stage in this category of patients.
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