Influence of lidokain on pressor hemodynamic reactions during the intration of trachea

The purpose of the study is a comparative assessment of the effect of lidocaine and fentanyl on pressor hemodynamic reactions during tracheal intubation. In response to the tracheal intubation, the heart rate increased after administration of 4 μg/kg of fentanyl by 15,2%, 1,5 mg/kg of lidocaine by 33,1%, combinations of 4 μg/kg of fentanyl and 1.5 mg/kg of lidocaine by 12,4% compared to baseline. MAP increased after administration of 4 µg/kg of fentanyl by 9,5%, 1,5 mg/kg of lidocaine - by 20,2%, combinations of 4 µg/kg of fentanyl and 1.5 mg/kg of lidocaine - by 7,6%. After tracheal intubation, the RPP level increased in fentanyl group by 27,7%, in the lidocaine group - the maximum increase in RPP after intubation was almost 60% in the fentanyl-lidocaine combination group, the maximum increase in RPP was 23,1%. Thus, to prevent an increase in NAP, HR, and reduce myocardial oxygen demand in response to laryngoscopy and tracheal intubation, intravenous administration of fentanyl at a dose of 4 μg / kg is advisable before performing tracheal intubation.