Expansion of the thoracic aorta and the activity of transforming growth factor-β in patients with marfanoid habitus

This article presents data on features of the thoracic aorta in patients with marfanoid habitus (MH) in various age groups. In patients of young age detected relatively larger diameter of aortic root, 25% of older patients with MH taped meaningful expansion of the aorta (Z-criterion > 2.0). As a pathogenetic basics remodeling of aorta in MH proven signaling pathway activation influence transforming growth factor-β - 45% of patients with MH exceeded the threshold of this cytokine.